RtsA Coordinately Regulates DsbA and the Salmonella Pathogenicity Island 1 Type III Secretion System

The Salmonella pathogenicity island-1 type III secretion system.

Salmonella pathogenicity island 1 (SPI1) encodes a type III secretion system that is required for virulence during the intestinal phase of infection. The expression of SPI1 genes is controlled by many global regulatory pathways that affect the expression/activity of transcriptional regulators encoded on SPI1.

Fur regulates expression of the Salmonella pathogenicity island 1 type III secretion system through HilD.

The invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium is mediated by a type III secretion system (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1). Expression of the SPI1 T3SS is tightly regulated by the combined action of HilC, HilD, and RtsA, three AraC family members that can independently activate hilA, which encodes the direct regulator of the SPI1...

Molecular mechanisms of Salmonella invasion: the type III secretion system of the pathogenicity island 1.

Salmonella spp. are facultative intracellular pathogens which are able to enter into non-phagocytic cells as an essential step in their pathogenic life cycle. The majority of the molecular determinants involved in this entry process are encoded in a pathogenicity island located at the centisome 63 of the bacterial chromosome, and belong to a specialized protein secretion system termed "type III...

Integrating global regulatory input into the Salmonella pathogenicity island 1 type III secretion system.

Salmonella enterica serovar Typhimurium uses the Salmonella pathogenicity island 1 (SPI1) type III secretion system to induce inflammatory diarrhea and bacterial uptake into intestinal epithelial cells. The expression of hilA, encoding the transcriptional activator of the SPI1 structural genes, is directly controlled by three AraC-like regulators, HilD, HilC, and RtsA, each of which can activat...

The Salmonella Pathogenicity Island-1 and -2 Encoded Type III Secretion Systems